Dissecting early development of the kidney by single cell transcriptomics
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چکیده
منابع مشابه
Exploring the Complexity of Cortical Development Using Single-Cell Transcriptomics
The developing neocortex in the mammalian brain is composed of multiple cell types including apical progenitors (AP), basal progenitors (BP), and neurons that populate three different layers, the ventricular zone (VZ), the subventricular zone (SVZ), and the cortical plate (CP). Despite recent advances, the diversity of the existing cell populations including those which are differentiating and ...
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Molecular changes underlying stem cell differentiation are of fundamental interest. scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 separated the cells into 3 main clusters with distinct features: active, quiescent, and an un-characterized cluster. Induction of anemia resulted in mobilization of the quiescent to the active cluster and of the early to later stage of cel...
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In our ever-changing environment, we are frequently exposed to uncontrollable, threatening social or physical stimuli that are perceived as stress. The brain rapidly mounts a stress response, by releasing neurotransmitters, hormones and peptides-stress mediators-that orchestrate organism-wide changes in an attempt to meet the challenges of the stressful situation. Despite the adaptive value of ...
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Nervous systems are composed of various cell types, but the extent of cell type diversity is poorly understood. We construct a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing. We identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types. We also analyzed cell type–specific ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2019
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.153.61